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KMID : 0354419770050010021
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Medical Postgraduate
1977 Volume.5 No. 1 p.21 ~ p.26
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Plasma Gastrin Response to Sanatogen in Patients with Far-Advanced Gastric Cancer
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성호경
고주환/유용운/서성희/김진용/이장규
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Abstract
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To detect abnormalities in the secretion of gastrin in eleven patients with various gastric cancer, their responses to sanatogen load were compared to those of healthy subjects. The patients were composed of two diffusely involved, two upper body and six antral portion cancers and a patient gastrectomized. After an overnight fase, the examination was done between 9:00 and 10:00 a.m. Blood samples were collected for thirty minutes after sanatogen loads and plasma gastrin concentrations were measured by the radioimmunoassay.
Results were as follows :
1. The fasting plasma gastrin concentrations for the whole patients showed no detectable differences between the cancer portions, although the concentration in the patients reached about twice those of six healthy young subjects. These results indicated that the older age rather than the disease itself is the major factor arising higher basal gastrin concentration.
2. When the prefeeding gastrin concentration was subtracted from the gastrin responses to sanatogen then the responses for the diffuse-and antral cancer patients were significantly greater than that of healthy subjects.
3. The gastrin responses for the upper body cancer showed conflicting results.
4. No gastrin response to feeding was observed in a gastrectomized patient, Above results suggested that the patients with gastric cancer reflect significantly higher gastrin response only when the disease involves antral portion.
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